The platform that supports our pipeline starts with a crystal structure and ends with a development candidate. In between is a sequence of steps that we measure carefully, because each one is a chance to fail safely and early.
Today, the median time from structure to development candidate is 24 months across our last three programs. We track that figure for every program and report it each quarter.
This article walks through the four steps we measure: target engagement, selectivity profiling, in vivo pharmacology, and candidate nomination. Each step has a defined go/no-go criterion. When a program misses a criterion, we stop it. That discipline is the platform.